Neurology Newsfeed
TOPAMAX360.com helps keep you current with real-time breaking news in the field of neurology
Click on the headlines below to see the full article.
Isolated Lateral Sinus Thrombosis. A Series of 62 Patients
Damak M et al. - Isolated lateral sinus thrombosis is a frequent variety of CVT, accounting for one third of all CVT. It presents in more than two thirds of cases with headache as the only symptom eit...Tue, 06 Jan 2009 00:00:00 EST
Migraine Predicts Self-Reported Muscle Tension in Patients With Major Depressive Disorder
Hung CI et al. - Of 135 participants with MDD, 63 (46.7%) had migraine. Multiple-regression analyses showed that migraine and headache intensity were two major independent factors related to SMT.......Tue, 06 Jan 2009 00:00:00 EST
Psychological issues in the evaluation and treatment of tension-type headache
Rosen NL et al. - Tension-type headache (TTH) is a common disease that is usually minimally impairing. However, more chronic TTH can be associated with significant disability and psychological comor...Mon, 05 Jan 2009 00:00:00 EST
Advances in the pharmacologic treatment of tension-type headache
Bigal ME et al. - For preventive treatment, amitriptyline is the best-studied drug, but nortriptyline, mirtazapine, tizanidine, the selective serotonin reuptake inhibitors, and other medications can...Mon, 05 Jan 2009 00:00:00 EST
New Migraine Drug Shows Promise
A drug called telcagepant proved safe and effective in treating migraines and caused fewer side effects than the widely-used migraine drug zolmitriptan (Zomig), according to a study.......Wed, 31 Dec 2008 00:00:00 EST
Decision making in patients with temporal lobe epilepsy
Labudda K et al. - The results demonstrate for the first time that presurgical patients with TLE can have selective reductions in decision making and that these deficits can result from...Mon, 05 Jan 2009 00:00:00 EST
Utility of Lumbar Puncture for First Simple Febrile Seizure Among Children 6 to 18 Months of Age
Kimia AA et al. - The risk of bacterial meningitis presenting as first simple febrile seizure at ages 6 to 18 months is very low. Current American Academy of Pediatrics recommendations ...Mon, 05 Jan 2009 00:00:00 EST
Seizures and Status Epilepticus in the Intensive Care Unit
Ziai WC et al. - The review takes the perspective of the neurological consultant in the intensive care unit, and considers all pharmacological approaches available to the intensivist as...Wed, 31 Dec 2008 00:00:00 EST
Radiographic Contrast Infusion and Catecholamine Release in Patients With Pheochromocytoma
Baid SK et al. - Intravenous low-osmolar contrast ndash;enhanced CT can safely be used in patients with pheochromocytoma who are not receiving [alpha]- or [beta]-blockers.......Tue, 06 Jan 2009 00:00:00 EST
What are the keys to successful adrenal venous sampling (AVS) in patients with primary aldosteronism
Young WF et al. - Adrenal venous sampling (AVS) is the criterion standard to distinguish between unilateral and bilateral adrenal disease in patients with primary aldosteroni...Tue, 06 Jan 2009 00:00:00 EST
Sellar and suprasellar mixed germ cell tumor mimicking a pituitary adenoma
Wildemberg LEA et al. - Although pituitary adenomas respond for the vast majority of sellar tumors, concomitant symptoms such as central diabetes insipidus and rapid tumor gr...Tue, 06 Jan 2009 00:00:00 EST
Stepping Responses of Infants With Myelomeningocele When Supported on a Motorized Treadmill
Teulier C et al. - Infants with MMC responded to the treadmill by stepping (but less so than infants with TD) and showing increased motor activity, but they demonstrated a di...Tue, 06 Jan 2009 00:00:00 EST
Lower-Extremity Strength Differences Predict Activity Limitations in People With Chronic Stroke
Kluding P et al. - Strength deficits in the hemiparetic lower extremity should be an important target for clinical interventions to improve function in people with chronic stroke.......Tue, 06 Jan 2009 00:00:00 EST
Post-polio syndrome: epidemiologic and prognostic aspects in Brazil
Conde MTRP et al. - Health professionals should carefully evaluate polio survivors for PPS and be aware of the implications of muscle overuse in the neurological recovery period. ......Tue, 06 Jan 2009 00:00:00 EST
Sciatic Nerve Entrapment in Associated Both-Column Acetabular Fractures: A Report of 2 Cases and Review of the Literature
Dunbar RP et al. - The authors report 2 patients with sciatic nerve entrapment within the posterior column components of their associated both-column acetabular fractures. Following ...Tue, 06 Jan 2009 00:00:00 EST
Mitochondrial involvement in psychiatric disorders
Shao L et al. - Specific evidence of dysfunction such as increased common deletion and decreased gene expression in mitochondria in psychiatric illnesses suggests that direct examina...Tue, 06 Jan 2009 00:00:00 EST
Dispensing errors have been reported between TOPAMAX® (topiramate) Tablets and TOPROL-XL® (metoprolol succinate) extended-release Tablets.
Please be sure to check your tablets to ensure you are taking the right medicine.
*TOPROL-XL is a registered trademark of the AstraZeneca group of companies.
TOPAMAX Tablets and TOPAMAX Sprinkle Capsules are indicated for adults for the prophylaxis of migraine headache. The usefulness of TOPAMAX in the acute treatment of migraine headache has not been studied.
TOPAMAX is contraindicated in patients with a history of hypersensitivity to any component of this product.
IMPORTANT SAFETY INFORMATION
TOPAMAX has been associated with serious adverse events, including:
- Hyperchloremic, non-anion gap metabolic acidosis - lowering of bicarbonate levels in the blood. Measurement of baseline and periodic serum bicarbonate is recommended.
- Acute myopia and secondary angle-closure glaucoma - patients should be cautioned to seek medical attention if they experience blurred vision or ocular pain.
- Oligohidrosis and hyperthermia - decreased sweating and increased body temperature, especially in hot weather. The majority of reports have been in children.
- Cognitive/psychiatric side effects including cognitive dysfunction, psychiatric/behavioral disturbances, including suicidal thoughts or behavior, and somnolence and fatigue.
Most common adverse events associated with TOPAMAX 100 mg vs placebo were: paresthesia, 51% vs 6%; anorexia,* 15% vs 6%; fatigue, 15% vs 11%; nausea, 13% vs 8%; diarrhea, 11% vs 4%; weight decrease, 9% vs 1%; taste alteration, 8% vs 1%.
The possibility of decreased contraceptive efficacy and increased breakthrough bleeding should be considered in patients taking combination oral contraceptive products with TOPAMAX.
Patients should be instructed to maintain an adequate fluid intake in order to minimize the risk of renal stone formation.
*Anorexia is defined as loss of appetite
Please see full U.S. Prescribing Information
